An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction

TS Sumida, MR Lincoln, L He, Y Park, M Ota… - Science Translational …, 2024 - science.org
Autoimmune diseases, among the most common disorders of young adults, are mediated by
genetic and environmental factors. Although CD4+ FOXP3+ regulatory T cells (Tregs) play a …

SVA Regulation of Transposable Element Clustered Transcription within the Major Histocompatibility Complex Genomic Class II Region of the Parkinson's …

JK Kulski, AL Pfaff, S Koks - Genes, 2024 - pmc.ncbi.nlm.nih.gov
SINE-VNTR-Alu (SVA) retrotransposons can regulate expression quantitative trait loci
(eQTL) of coding and noncoding genes including transposable elements (TEs) distributed …

Targeting Noncoding cis-Regulatory Elements for Cancer Therapy in the Context of the 3D Genome

K Li, GH Wei, Y Yin, J Feng - Cancer Discovery, 2024 - aacrjournals.org
Significant efforts have been made to identify and validate oncoproteins and ncRNAs as
therapeutic targets for cancer therapy; however, emerging observations suggest that …