The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …
every area of neuroscience. Initial reports focused on classical immune functions of …
Single-cell RNA-sequencing: astrocyte and microglial heterogeneity in health and disease
MS Spurgat, SJ Tang - Cells, 2022 - mdpi.com
Astrocytes and microglia are non-neuronal cells that maintain homeostasis within the central
nervous system via their capacity to regulate neuronal transmission and prune synapses …
nervous system via their capacity to regulate neuronal transmission and prune synapses …
Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
Immune system and blood–brain barrier dysfunction are implicated in the development of
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases
R Lang, H Li, X Luo, C Liu, Y Zhang, SY Guo… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-
stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression …
stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression …
CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination
Neurotropic mouse hepatitis virus (MHV-A59/RSA59) infection in mice induces acute
neuroinflammation due to direct neural cell dystrophy, which proceeds with demyelination …
neuroinflammation due to direct neural cell dystrophy, which proceeds with demyelination …
[HTML][HTML] Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine β-coronavirus-induced neuroinflammation
Mouse hepatitis virus (MHV; m-β-CoV) serves as a useful model for studying the cellular
factors involved in neuroinflammation. To understand the role of matrix metalloproteinases …
factors involved in neuroinflammation. To understand the role of matrix metalloproteinases …
The interferon-induced protein with tetratricopeptide repeats repress influenza virus infection by inhibiting viral RNA synthesis
Influenza A virus (IAV) is an eight-segment negative-sense RNA virus and is subjected to
gene recombination between strains to form novel strains, which may lead to influenza …
gene recombination between strains to form novel strains, which may lead to influenza …
[HTML][HTML] Reference-quality bat genomes illuminate adaptations to viral tolerance and disease resistance
Bats carry viruses that can cause severe disease in other mammals. Asymptomatic
infections in bats suggest limited tissue-damaging inflammation and immunopathology. To …
infections in bats suggest limited tissue-damaging inflammation and immunopathology. To …
IFN-induced protein with tetratricopeptide repeats 2 limits autoimmune inflammation by regulating myeloid cell activation and metabolic activity
IFN-Induced Protein with Tetratricopeptide Repeats 2 Limits Autoimmune Inflammation by
Regulating Myeloid Cell Activation and Metabolic Activity | The Journal of Immunology …
Regulating Myeloid Cell Activation and Metabolic Activity | The Journal of Immunology …
Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology
M Sharma, D Chakravarty, A Hussain… - Journal of …, 2023 - Am Soc Microbiol
Interferon-induced protein with tetratricopeptide repeats 2, Ifit2, is critical in restricting
neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2 …
neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2 …