SARS-CoV-2 epitope-specific T cells: Immunity response feature, TCR repertoire characteristics and cross-reactivity

G Yang, J Wang, P Sun, J Qin, X Yang, D Chen… - Frontiers in …, 2023 - frontiersin.org
The devastating COVID-19 pandemic caused by SARS-CoV-2 and multiple variants or
subvariants remains an ongoing global challenge. SARS-CoV-2-specific T cell responses …

Unravelling influenza correlates of protection: lessons from human A/H1N1 Challenge

RJ Cox, R Pathirana - Mbio, 2024 - Am Soc Microbiol
Mucosal immunity is important in protecting from upper respiratory tract influenza infection.
Human challenge provides a unique model to define correlates of protection with baseline …

Meeting Report From “Correlates of Protection for Next Generation Influenza Vaccines: Lessons Learned From the COVID‐19 Pandemic”

F Krammer, JM Katz, OG Engelhardt… - Influenza and Other …, 2024 - Wiley Online Library
Background This report summarizes the discussions and conclusions from the “Correlates of
Protection for Next Generation Influenza Vaccines: Lessons Learned from the COVID‐19 …

Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI. 4 and GII. 4 VLPs without adjuvant

G Waerlop, Y Janssens, B Jacobs… - Frontiers in …, 2023 - frontiersin.org
The development of an efficacious vaccine against norovirus is of paramount importance
given its potential to reduce the global burden of norovirus-associated morbidity and …

Proficiency tests to evaluate the impact on assay outcomes of harmonized influenza-specific intracellular cytokine staining (ICS) and IFN-Ɣ enzyme-linked …

G Waerlop, G Leroux-Roels, A Pagnon, S Begue… - Journal of …, 2023 - Elsevier
The magnitude and quality of cell-mediated immune responses elicited by natural infection
or vaccination are commonly measured by Interferon-ɣ (IFN-ɣ) Enzyme-Linked …

[HTML][HTML] Validation of the Enzyme-Linked ImmunoSpot Analytic Method for the Detection of Human IFN-γ from Peripheral Blood Mononuclear Cells in Response to the …

LE Carreto-Binaghi, M Nieto-Ponce, A Palencia-Reyes… - Biomolecules, 2024 - mdpi.com
COVID-19 vaccine evaluations are mainly focused on antibody analyses, but there is
growing interest in measuring the cellular immune responses from the researchers …

Inno4Vac Workshop Report Part 1: Controlled Human Influenza Virus Infection Model (CHIVIM) Strain Selection and Immune Assays for CHIVIM Studies, November …

J Waldock, RJ Cox, C Chiu, K Subbarao… - Influenza and Other …, 2024 - Wiley Online Library
Controlled human infection models (CHIMs) are a critical tool for the understanding of
infectious disease progression, characterising immune responses to infection and rapid …

Validation of an interferon-gamma enzyme-linked immunosorbent spot assay to evaluate cell-mediated immunity against severe acute respiratory syndrome …

Y Kim, EJ Jang, JY Hwang, KM Lee… - Human Vaccines & …, 2024 - Taylor & Francis
The COVID-19 pandemic forced the rapid development of methods to measure humoral and
cellular immunity against SARS-CoV-2. The lack of a global standardized protocol and the …

Meeting Report: Controlled Human Influenza Virus Infection Model Studies: Current Status and Future Directions for Innovation

MC Lane, CJ Luke, J Bresee, VG Dugan… - Influenza and Other …, 2024 - Wiley Online Library
ABSTRACT On November 13–14, 2023, the National Institute of Allergy and Infectious
Diseases (NIAID) in partnership with the Task Force for Global Health, Flu Lab, the …

[HTML][HTML] Validation of a double-color ELISpot assay of IFN-γ and IL-4 production in human peripheral blood mononuclear cells

F Dapporto, D De Tommaso, C Marrocco, P Piu… - Journal of …, 2024 - Elsevier
Abstract The Enzyme-Linked ImmunoSpot (ELISpot) assay detects cytokines secreted
during T cell-specific immune responses against pathogens. As this assay has acquired …