Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

Context Chitosan is a biocompatible polysaccharide that has been widely exploited in
biomedical and drug delivery applications. Objective This study explores the renoprotective …

Owing to advances in modern medicine, life expectancies are lengthening and leading to an
increase in the population of older individuals. The aging process leads to significant …

Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …

The mitochondria are a major source of reactive oxygen species (ROS). Superoxide anion
(O2•–) is produced by the process of oxidative phosphorylation associated with glucose …

The end products of polyunsaturated fatty acid (PUFA) peroxidation, such as
malondialdehyde (MDA), 4-hydroxynonenal (HNE), and isoprostanes (8-iso-PGF 2α), are …

Although age-associated changes in kidney glomerular architecture have been described in
mice and man, the mechanisms are unknown. It is unclear if these changes can be …

Oxidative stress is implicated in the pathogenesis and/or maintenance of elevated blood
pressure in hypertension. This study investigated the effect of honey on elevated systolic …

Objective: To explore the effects of long non-coding RNA (lncRNA) brain-derived
neurotrophic factor anti-sense (BDNF-AS) on the Aβ25-35-induced neurotoxicity in PC12 …