Stimuli-responsive nanobubbles have received increased attention for their application in
spatial and temporal resolution of diagnostic techniques and therapies, particularly in …

Ultrasound-responsive polymeric materials have received a tremendous amount of attention
from scientists for several decades. Compared to other stimuli-responsive materials (such as …

This Special Issue on the enhanced permeability and retention (EPR) effect commemorates
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …

Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …

Heat-triggered drug release from temperature-sensitive nanocarriers upon the application of
mild hyperthermia is a promising approach to achieve site-specific delivery of drugs. The …

Ultrasound (US) is a mechanical wave that can penetrate biological tissues and trigger
complex bioeffects. The mechanisms of US in different diagnosis and treatment are different …

Because of their size (1–10 μm), microbubble-based drug delivery agents suffer from
confinement to the vasculature, limiting tumor penetration and potentially reducing the drug …

The field of medical ultrasound has undergone a significant evolution since the development
of microbubbles as contrast agents. However, because of their size, microbubbles remain in …

The non-specific distribution, non-selectivity towards cancerous cells, and adverse off-target
side effects of anticancer drugs and other therapeutic molecules lead to their inferior clinical …

Cancer is still a leading cause of deaths worldwide, especially due to those cases
diagnosed at late stages with metastases that are still considered untreatable and are …