The Functional Significance of High Cysteine Content in Eye Lens γ-Crystallins
Cataract disease is strongly associated with progressively accumulating oxidative damage
to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin …
to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin …
Structure and Substrate Specificity of S-Methyl Thiourocanate Hydratase
CM Vasseur, D Karunasegaram… - ACS Chemical …, 2024 - ACS Publications
Nicotinamide adenine dinucleotide (NAD+) is a common cofactor in enzyme-catalyzed
reactions that involve hydride transfers. In contrast, urocanase and urocanase-like enzymes …
reactions that involve hydride transfers. In contrast, urocanase and urocanase-like enzymes …
Recent advances in developing highly atom-economic C–H annulation reactions in water
Atom-economy (AE) is the fundamental and most important parameter of green chemistry
since the higher the AE of a reaction lesser is the waste generation. C–H annulation, ie …
since the higher the AE of a reaction lesser is the waste generation. C–H annulation, ie …
Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507
H Hu, L Li, Z Shi, X Lan, Y Zhang… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Psoriasis is a chronic immune‐mediated inflammatory skin
disease and the TNF‐α is an important therapeutic target of this disease. In our continuous …
disease and the TNF‐α is an important therapeutic target of this disease. In our continuous …
First Fragment-based Screening Identifies New Chemotypes Inhibiting ERAP1-Metalloprotease
V Fougiaxis, V Barcherini, MM Petrovic… - European Journal of …, 2024 - Elsevier
Inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) by small-molecules is being
eagerly investigated for the treatment of various autoimmune diseases and in the field of …
eagerly investigated for the treatment of various autoimmune diseases and in the field of …
Columnar Mesomorphism in a Methylthio-Decorated Triindole for Enhanced Charge Transport
C Ruiz, R Martín, A Benito, E Gutierrez… - ACS Applied …, 2024 - ACS Publications
We report a semiconducting triindole-based discotic liquid crystal (TRISMe) functionalized
with six p-methylthiophenyl groups at its periphery. While initially a crystalline solid at room …
with six p-methylthiophenyl groups at its periphery. While initially a crystalline solid at room …
Optical and molecular characteristics of urban wastewater dissolved organic matter: insights into their correlations
J Chu, Z Liao - Environmental Science: Water Research & Technology, 2024 - pubs.rsc.org
Urban domestic wastewater is a significant source of dissolved organic matter (DOM) in
aquatic environments, critically impacting urban water quality. This study integrates the …
aquatic environments, critically impacting urban water quality. This study integrates the …
Importance of Noncovalent Interactions Involving Sulfur Atoms in Thiopeptide Antibiotics─ Glycothiohexide α and Nocathiacin I
V Kojasoy, DJ Tantillo - The Journal of Physical Chemistry A, 2023 - ACS Publications
Noncovalent interactions involving sulfur atoms play essential roles in protein structure and
function by significantly contributing to protein stability, folding, and biological activity. Sulfur …
function by significantly contributing to protein stability, folding, and biological activity. Sulfur …
Polyoxometalate‐Polymer Directed Macromolecular Architectonics of Silver Nanoparticles as Effective Antimicrobials
A novel inorganic‐organic‐inorganic ternary bioactive material formulated on antimicrobial
peptide‐based polymer has been reported. Supramolecular approach has been employed …
peptide‐based polymer has been reported. Supramolecular approach has been employed …
Quantitative evaluation of the electronic features involving “nucleophilic–electrophilic” character in the chalcogen sulfur
This study investigates the crystal structures of substituted thiophenes and isothiocyanates
by utilizing the method of in situ cryo-crystallization to gain quantitative insights into the …
by utilizing the method of in situ cryo-crystallization to gain quantitative insights into the …