The Functional Significance of High Cysteine Content in Eye Lens γ-Crystallins

E Serebryany, RW Martin, GR Takahashi - Biomolecules, 2024 - mdpi.com
Cataract disease is strongly associated with progressively accumulating oxidative damage
to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin …

Structure and Substrate Specificity of S-Methyl Thiourocanate Hydratase

CM Vasseur, D Karunasegaram… - ACS Chemical …, 2024 - ACS Publications
Nicotinamide adenine dinucleotide (NAD+) is a common cofactor in enzyme-catalyzed
reactions that involve hydride transfers. In contrast, urocanase and urocanase-like enzymes …

Recent advances in developing highly atom-economic C–H annulation reactions in water

T Chatterjee, P Pattanayak, ANV Satyanarayana… - Current Opinion in …, 2023 - Elsevier
Atom-economy (AE) is the fundamental and most important parameter of green chemistry
since the higher the AE of a reaction lesser is the waste generation. C–H annulation, ie …

Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

H Hu, L Li, Z Shi, X Lan, Y Zhang… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Psoriasis is a chronic immune‐mediated inflammatory skin
disease and the TNF‐α is an important therapeutic target of this disease. In our continuous …

First Fragment-based Screening Identifies New Chemotypes Inhibiting ERAP1-Metalloprotease

V Fougiaxis, V Barcherini, MM Petrovic… - European Journal of …, 2024 - Elsevier
Inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) by small-molecules is being
eagerly investigated for the treatment of various autoimmune diseases and in the field of …

Columnar Mesomorphism in a Methylthio-Decorated Triindole for Enhanced Charge Transport

C Ruiz, R Martín, A Benito, E Gutierrez… - ACS Applied …, 2024 - ACS Publications
We report a semiconducting triindole-based discotic liquid crystal (TRISMe) functionalized
with six p-methylthiophenyl groups at its periphery. While initially a crystalline solid at room …

Optical and molecular characteristics of urban wastewater dissolved organic matter: insights into their correlations

J Chu, Z Liao - Environmental Science: Water Research & Technology, 2024 - pubs.rsc.org
Urban domestic wastewater is a significant source of dissolved organic matter (DOM) in
aquatic environments, critically impacting urban water quality. This study integrates the …

Importance of Noncovalent Interactions Involving Sulfur Atoms in Thiopeptide Antibiotics─ Glycothiohexide α and Nocathiacin I

V Kojasoy, DJ Tantillo - The Journal of Physical Chemistry A, 2023 - ACS Publications
Noncovalent interactions involving sulfur atoms play essential roles in protein structure and
function by significantly contributing to protein stability, folding, and biological activity. Sulfur …

Polyoxometalate‐Polymer Directed Macromolecular Architectonics of Silver Nanoparticles as Effective Antimicrobials

LP Datta, D Dutta, R Mukherjee… - Chemistry–An Asian …, 2024 - Wiley Online Library
A novel inorganic‐organic‐inorganic ternary bioactive material formulated on antimicrobial
peptide‐based polymer has been reported. Supramolecular approach has been employed …

Quantitative evaluation of the electronic features involving “nucleophilic–electrophilic” character in the chalcogen sulfur

K Mandal, A Hasija, R Shukla, VR Hathwar… - Physical Chemistry …, 2023 - pubs.rsc.org
This study investigates the crystal structures of substituted thiophenes and isothiocyanates
by utilizing the method of in situ cryo-crystallization to gain quantitative insights into the …