The recent discovery of extrasolar Earth-like planets that orbit in their habitable zone of their
system, and the latest clues of the presence of liquid water in the subsurface of Mars and in …

Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains
target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis …

Modification of proteins by ubiquitin is a highly regulated process that plays a critical role in
eukaryotes, from the construction of signalling platforms to the control of cell division …

The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the
regulation of numerous cellular processes. Yet, the mechanisms that govern the selective …

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in
transcription, genome maintenance, and proteostasis. The contributions of many conserved …

Histone H2B monoubiquitination in budding yeast is a highly conserved post-translational
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …

Purpose Ixazomib is a selective, effective, and reversible inhibitor of 20S proteasome and is
approved for the treatment of multiple myeloma. Ubiquitin-conjugating enzyme E2 (UBE2K) …

Abstract Ubiquitin-conjugating enzymes (E2) form thioester bonds with ubiquitin (Ub), which
are subsequently transferred to target proteins for cellular progress. Ube2K/E2-25K (a class …

The ubiquitination pathway is central to many cell signaling and regulatory events. One of
the intriguing aspects of the pathway is the combinatorial sophistication of substrate …

The design of Artificial Metalloenzymes (ArMs), which result from the incorporation of
organometallic cofactors into biological structures, has grown steadily in the last two …