[HTML][HTML] Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta
W Chatuphonprasert, K Jarukamjorn… - Frontiers in …, 2018 - frontiersin.org
The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as
their precursor cholesterol are required for successful establishment and maintenance of …
their precursor cholesterol are required for successful establishment and maintenance of …
The serum vitamin D metabolome: What we know and what is still to discover
RC Tuckey, CYS Cheng, AT Slominski - The Journal of steroid biochemistry …, 2019 - Elsevier
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …
phototransformation in the skin, is a prohormone important in human health. The most …
[图书][B] Melatoninergic system in the skin
Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
Photoprotective properties of vitamin D and lumisterol hydroxyderivatives
AT Slominski, A Chaiprasongsuk, Z Janjetovic… - Cell biochemistry and …, 2020 - Springer
We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
Novel activities of CYP11A1 and their potential physiological significance
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders
RM Slominski, RC Tuckey, PR Manna, AM Jetten… - Genes & …, 2020 - nature.com
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D
AT Slominski, TK Kim, Y Takeda, Z Janjetovic… - The FASEB …, 2014 - ncbi.nlm.nih.gov
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
The significance of CYP11A1 expression in skin physiology and pathology
RM Slominski, C Raman, C Elmets, AM Jetten… - Molecular and cellular …, 2021 - Elsevier
CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
N Strushkevich, F MacKenzie… - Proceedings of the …, 2011 - National Acad Sciences
In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from
cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin …
cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin …