Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in
age-related metabolic decline. To date, the mechanism responsible for the age-related …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Aging is characterized by the development of metabolic dysfunction and frailty. Recent
studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for …

Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …

Caloric restriction (CR) extends the life span and health span of a variety of species and
slows the progression of age-related hearing loss (AHL), a common age-related disorder …

A molecule that treats multiple age-related diseases would have a major impact on global
health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target …

A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …

Histone post-translational modifications regulate transcription and other DNA-templated
functions. This process is dynamically regulated by specific modifying enzymes whose …