Current Understandings and Open Hypotheses on Extracellular Circular RNAs

J Verwilt, M Vromman - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Circular RNAs (circRNAs) are closed RNA loops present in humans and other organisms.
Various circRNAs have an essential role in diseases, including cancer. Cells can release …

Engineering circular RNA medicines

X Cao, Z Cai, J Zhang, F Zhao - Nature Reviews Bioengineering, 2024 - nature.com
Circular RNAs (circRNAs) are a group of RNA molecules prevalent across various
organisms and tissues and characterized by a covalent loop structure. Their unique …

[HTML][HTML] Circular RNAs in Cardiovascular Diseases: Molecular Mechanisms, Therapeutic Advances, and Innovations

Z Yuan, S Huang, X Jin, S Li - Genes, 2024 - mdpi.com
Circular RNAs (circRNAs) have emerged as promising therapeutic targets due to their
unique covalently closed-loop structures and their regulatory roles in gene expression …

RNA denaturation underlies circular RNA separation

Y Jiang, J Kjems - bioRxiv, 2025 - biorxiv.org
In vitro synthesized circular RNAs (circRNAs) have emerged as a promising drug modality
for RNA therapeutics due to their improved stability and reduced immunogenicity. However …