Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Estrogenic hormones, believed to exert most of their effects via the direct interaction of their
receptors with chromatin, are found to increase cAMP in target breast cancer and uterine …

cDNA encoding a novel phosphodiesterase (PDE) was isolated from a human fetal lung
cDNA library and designated PDE10A. The deduced amino acid sequence contains 779 …

Sulindac sulfone (exisulind), although a nonsteroidal anti-inflammatory drug derivative,
induces apoptosis in tumor cells by a mechanism that does not involve cyclooxygenase …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-
benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity …

Mutants of Saccharomyces cerevisiae that require cAMP for growth have been isolated.
Some of the mutants isolated were deficient in adenylate cyclase activity and mapped at a …

Increased cyclic AMP-phosphodiesterase activity in peripheral blood leukocytes is
associated with the immune and inflammatory hyperreactivity that char-acterizes atopic …

Previous studies have documented that leukocytes from atopic individuals show reduced
cyclic AMP (cAMP) responsiveness to isoproterenol, histamine, and prostaglandin E 1. We …

When Chlamydomonas reinhardtii gametes of opposite mating type are mixed together, they
adhere by a flagella-mediated agglutination that triggers three rapid mating responses …