Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use
than any other foreign compound–metabolizing enzyme in humans. Recently, increasing …

The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced
enzyme function. We aimed to evaluate the influence of these alleles on the …

Simple Summary The effectiveness and safety of the anti-cancer agent doxorubicin
(anthracycline group medicine) depend on the metabolism and retention of the drug in the …

Background and Objective The association between the CYP3A4* 1B single nucleotide
polymorphism (SNP) and tacrolimus pharmacokinetics in different studies is controversial …

Tacrolimus, a dual substrate of CYP3A4 and CYP3A5 has a narrow therapeutic index and is
characterized by high between-subject variability in oral bioavailability. This study …

Background: Tacrolimus (TAC), acting as a calcineurin inhibitor, is an immunosuppressant
widely used after kidney transplantation. TAC requires blood concentration monitoring due …

Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the
liver, responsible for the oxidative metabolism of∼ 50% of clinically prescribed drugs …

Aim In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading
dose of 0.2 mg/kg, the combined effects of the CYP3A5* 1, POR* 28, and CYP3A4* 22 …

OBJECTIVE: To identify genetic variants that influence steady-state etonogestrel
concentrations among contraceptive implant users. METHODS: We enrolled healthy …