Role of DNA methylation in the pathogenesis and treatment of myelodysplastic syndromes
The myelodysplastic syndromes (MDS) are a group of hematologic disorders characterized
by ineffective hematopoiesis and increased risk of transformation to acute myeloid leukemia …
by ineffective hematopoiesis and increased risk of transformation to acute myeloid leukemia …
[HTML][HTML] De novo and therapy-related myelodysplastic syndromes: analogies and differences
G Leone, E Fabiani, MT Voso - Mediterranean journal of …, 2022 - ncbi.nlm.nih.gov
The aim of our review has been to give an appropriate idea of analogies and differences
between primitive MDS (p-MDS) and t-MDS throughout an accurate reviewing of English …
between primitive MDS (p-MDS) and t-MDS throughout an accurate reviewing of English …
Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases
In this study we used a next generation sequencing-based approach to profile gene
mutations in therapy-related myelodysplastic syndromes (t-MDS) and acute myeloid …
mutations in therapy-related myelodysplastic syndromes (t-MDS) and acute myeloid …
Genomic impact of transient low-dose decitabine treatment on primary AML cells
JM Klco, DH Spencer, TL Lamprecht… - Blood, The Journal …, 2013 - ashpublications.org
Acute myeloid leukemia (AML) is characterized by dysregulated gene expression and
abnormal patterns of DNA methylation; the relationship between these events is unclear …
abnormal patterns of DNA methylation; the relationship between these events is unclear …
TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases
Background TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN)
than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t …
than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t …
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates
E-cadherin is a calcium-dependent cell-cell adhesion molecule extensively studied for its
involvement in tissue formation, epithelial cell behavior, and suppression of cancer …
involvement in tissue formation, epithelial cell behavior, and suppression of cancer …
Methylation of H2AR29 is a novel repressive PRMT6 target
T Waldmann, A Izzo, K Kamieniarz, F Richter… - Epigenetics & …, 2011 - Springer
Background Covalent histone modifications are central to all DNA-dependent processes.
Modifications of histones H3 and H4 are becoming well characterised, but knowledge of …
Modifications of histones H3 and H4 are becoming well characterised, but knowledge of …
The methylation status of the epigenome: its emerging role in the regulation of tumor angiogenesis and tumor growth, and potential for drug targeting
L Pirola, O Ciesielski, A Balcerczyk - Cancers, 2018 - mdpi.com
Approximately 50 years ago, Judah Folkman raised the concept of inhibiting tumor
angiogenesis for treating solid tumors. The development of anti-angiogenic drugs would …
angiogenesis for treating solid tumors. The development of anti-angiogenic drugs would …
A retrospective validation of the IPSS-M molecular score in primary and therapy-related myelodysplastic syndromes (MDS)
JMG Sabile, A Kaempf, K Tomic, GP Manu… - Leukemia & …, 2023 - Taylor & Francis
A molecular scoring system (IPSS-M) was recently proposed for myelodysplastic syndrome
(MDS). We conducted a retrospective study of adults with MDS referred 2019–2021. The …
(MDS). We conducted a retrospective study of adults with MDS referred 2019–2021. The …
Therapy-related myeloid neoplasms
The risk of t-MN is not negligible, although below 2% in most series. This is particularly
significant for younger cancer patients and during the first 5 years after the primary …
significant for younger cancer patients and during the first 5 years after the primary …