While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

Drug nanodelivery systems (DNDSs) are fascinated cargos to achieve outstanding
therapeutic results of various drugs or natural bioactive compounds owing to their unique …

Impaired circulating estrogen levels have been related to impaired glycemic homeostasis
and diabetes mellitus (DM), both in females and males. However, for the last twenty years …

Elevated circulating lactate has been associated with obesity and insulin resistance. The
aim of the current study was to determine if lactate-induced lysine lactylation (kla), a post …

The increasing prevalence of type 2 diabetes has become a major global problem. Insulin
resistance has a central role in pathophysiology of type 2 diabetes. Skeletal muscle is …

Purpose NAFLD is a hepatic component of type 2 diabetes mellitus (T2D), in which impaired
hepatic glucose production plays an important role. Inhibitors of sodium glucose transporter …

Diabetes mellitus (DM) is an important risk factor for dementia, which is a common
neurodegenerative disorder. DM is known to activate inflammation, oxidative stress, and …

Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in
these metabolic pathways is a significant risk factor for numerous acute and chronic …