Multimorbidity and functional impairment–bidirectional interplay, synergistic effects and common pathways

A Calderón‐Larrañaga, DL Vetrano… - Journal of internal …, 2019 - Wiley Online Library
This review discusses the interplay between multimorbidity (ie co‐occurrence of more than
one chronic health condition in an individual) and functional impairment (ie limitations in …

Polypharmacy and medication management in older adults

J Kim, AL Parish - Nursing Clinics, 2017 - nursing.theclinics.com
Although prescribed and over-the-counter medications may improve a wide range of health
problems, they also may cause or contribute to harm, especially in older adults. Current-day …

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): position statement and 10 recommendations for action

D Mangin, G Bahat, BA Golomb, LH Mallery… - Drugs & aging, 2018 - Springer
Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …

The prescribing cascade revisited

PA Rochon, JH Gurwitz - Lancet (London, England), 2017 - pubmed.ncbi.nlm.nih.gov
The prescribing cascade revisited The prescribing cascade revisited Lancet. 2017 May 6;389(10081):1778-1780.
doi: 10.1016/S0140-6736(17)31188-1. Epub 2017 May 4. Authors Paula A Rochon 1 , Jerry …

The challenge of managing drug interactions in elderly people

L Mallet, A Spinewine, A Huang - The Lancet, 2007 - thelancet.com
Drug therapy is essential when caring for elderly patients, but clearly it is a double-edged
sword. Elderly patients are at high risk of having drug interactions, but the prevalence of …

Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study

I Carrière, A Fourrier-Reglat, JF Dartigues… - Archives of internal …, 2009 - jamanetwork.com
Background Despite the high intake of medications with anticholinergic properties by
community-dwelling elderly persons, the effects on cognitive decline and dementia have …

Adverse drug reactions of acetylcholinesterase inhibitors in older people living with dementia: a comprehensive literature review

S Ruangritchankul, P Chantharit… - … and clinical risk …, 2021 - Taylor & Francis
The rising of global geriatric population has contributed to increased prevalence of
dementia. Dementia is a neurodegenerative disease, which is characterized by progressive …

Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence

A Collamati, AM Martone, A Poscia, V Brandi… - Aging clinical and …, 2016 - Springer
The use of medication with anticholinergic properties is widespread among older subjects.
Many drugs of common use such as antispasmodics, bronchodilators, antiarrhythmics …

Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study

SS Gill, GM Anderson, HD Fischer… - Archives of Internal …, 2009 - jamanetwork.com
Background Cholinesterase inhibitors are commonly prescribed to treat dementia, but their
adverse effect profile has received little attention. These drugs can provoke symptomatic …

[PDF][PDF] The pharmacological treatment of urinary incontinence

KE Andersson, R Appell, LD Cardozo, C Chapple… - BJU …, 1999 - academia.edu
The pharmacological treatment of urinary incontinence Page 1 BJU International (1999), 84,
923–947 REVIEW The pharmacological treatment of urinary incontinence K.-E …