Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Over the past decade, it was found that relatively simple sphingolipids, such as ceramide,
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex
glycosphingolipids play very important roles in cell function under physiological conditions …

The lipid second messenger ceramide regulates several biochemical events that occur
during aging. In addition, its level is highly elevated in the amyloid-burdened brains of …

Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis.
Although several apoptosis-inducing agents have been described, understanding of the …

Sphingolipid metabolites, such as ceramide, sphingosine, sphingosine-1-phosphate (S1P)
and complex sphingolipids (gangliosides), are recognized as molecules capable of …

Binding of nerve growth factor (NGF) to the p75 neurotrophin receptor (p75) in cultured
hippocampal neurons has been reported to cause seemingly contrasting effects, namely …

Sympathetic innervation of the adult rodent uterus undergoes cyclic remodelling. Terminal
sympathetic axons degenerate when oestrogen levels rise and regenerate when oestrogen …

Niemann Pick type C (NPC) disease is a progressive neurodegenerative disorder. In cells
lacking functional NPC1 protein, endocytosed cholesterol accumulates in late endosomes …

We previously reported that incubation of bone-marrow derived macrophages in the
absence of macrophage-colony stimulating factor (M-CSF), a cytokine that is essential for …