Factors influencing properties of spider silk coatings and their interactions within a biological environment

VT Trossmann, S Lentz, T Scheibel - Journal of Functional Biomaterials, 2023 - mdpi.com
Biomaterials are an indispensable part of biomedical research. However, although many
materials display suitable application-specific properties, they provide only poor …

Recombinant spidroins as the basis for new materials

VG Debabov, VG Bogush - ACS Biomaterials Science & …, 2020 - ACS Publications
Spider web proteins are unique materials created by nature that, considering the
combination of their properties, do not have analogues among natural or human-created …

Recombinant spider silk forms tough and elastic nanomembranes that are protein‐permeable and support cell attachment and growth

L Gustafsson, CP Tasiopoulos… - Advanced Functional …, 2020 - Wiley Online Library
Biologically compatible membranes are of high interest for several biological and medical
applications. Tissue engineering, for example, would greatly benefit from ultrathin, yet easy …

Boronic Acid-Tethered Silk Fibroin for pH-Dependent Mucoadhesion

L d'Amone, JK Sahoo, N Ostrovsky-Snider… - …, 2023 - ACS Publications
Mucus lines all surfaces of the human body not covered by skin and provides lubrication,
hydration, and protection. The properties of mucus are influenced by changes in pH that may …

Bioactive Silk Coatings Reduce the Adhesion of Staphylococcus aureus while Supporting Growth of Osteoblast-like Cells

L Nileback, M Widhe, J Seijsing, H Bysell… - … Applied Materials & …, 2019 - ACS Publications
Orthopedic and dental implants are associated with a substantial risk of failure due to
biomaterial-associated infections and poor osseointegration. To prevent such outcomes, a …

Assembly of functionalized silk together with cells to obtain proliferative 3D cultures integrated in a network of ECM-like microfibers

U Johansson, M Widhe, ND Shalaly, IL Arregui… - Scientific reports, 2019 - nature.com
Tissues are built of cells integrated in an extracellular matrix (ECM) which provides a three-
dimensional (3D) microfiber network with specific sites for cell anchorage. By genetic …

Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers

DH De Oliveira, V Gowda, T Sparrman… - Nature …, 2024 - nature.com
Abstract The major ampullate Spidroin 1 (MaSp1) is the main protein of the dragline spider
silk. The C-terminal (CT) domain of MaSp1 is crucial for the self-assembly into fibers but the …

Silk Assembly against Hydrophobic Surfaces─ Modeling and Imaging of Formation of Nanofibrils

DH De Oliveira, M Biler, C Mim, L Enstedt… - ACS Applied Bio …, 2023 - ACS Publications
A detailed insight about the molecular organization behind spider silk assembly is valuable
for the decoding of the unique properties of silk. The recombinant partial spider silk protein …

Self-assembly of RGD-functionalized recombinant spider silk protein into microspheres in physiological buffer and in the presence of hyaluronic acid

E Ornithopoulou, C Åstrand, L Gustafsson… - ACS Applied Bio …, 2023 - ACS Publications
Biomaterials made of self-assembling protein building blocks are widely explored for
biomedical applications, for example, as drug carriers, tissue engineering scaffolds, and …

Metastable Liquid–Liquid Phase Separation and Aging Lead to Strong Processing Path Dependence in Mini‐Spidroin Solutions

D Fedorov, FE Sammalisto, AL Harmat… - Advanced Functional …, 2024 - Wiley Online Library
Recombinant silk proteins provide a route toward sustainable and biocompatible materials.
For making such materials, the assembly process from dilute protein into a functional …