Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Niemann-Pick disease type C (NPC) is associated with mutations in NPC1 and NPC2,
whose gene products are key players in the endosomal/lysosomal egress of low-density …

Cholesterol is an essential component of animal cell membranes, and its concentration is
tightly controlled by a feedback system that operates at transcriptional and …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …

Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …

Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, an
important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids …

The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-
hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both …