Chaperones in polyglutamine aggregation: beyond the Q-stretch
Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to
inherited neuronal dysfunction and degeneration. The expansion size in all diseases …
inherited neuronal dysfunction and degeneration. The expansion size in all diseases …
The Extent of Human Apolipoprotein AI Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro
R Dal Magro, S Simonelli, A Cox, B Formicola… - Frontiers in …, 2019 - frontiersin.org
Much evidence suggests a protective role of high-density lipoprotein (HDL) and its major
apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived …
apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived …
Free energy landscape of siRNA-polycation complexation: Elucidating the effect of molecular geometry, polymer flexibility, and charge neutralization
The success of medical threatments with DNA and silencing interference RNA is strongly
related to the design of efficient delivery technologies. Cationic polymers represent an …
related to the design of efficient delivery technologies. Cationic polymers represent an …
Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA
The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the
genome” because of its ability to orchestrate protective biological outputs in response to a …
genome” because of its ability to orchestrate protective biological outputs in response to a …
Toward the design and development of peptidomimetic inhibitors of the Ataxin-1 aggregation pathway
Spinocerebellar ataxia type 1 is a degenerative disorder caused by polyglutamine
expansions and aggregation of Ataxin-1. The interaction between Capicua (CIC) and the …
expansions and aggregation of Ataxin-1. The interaction between Capicua (CIC) and the …
In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism
Alsin is a protein known for its major role in neuronal homeostasis and whose mutation is
associated with early-onset neurodegenerative diseases. It has been shown that its …
associated with early-onset neurodegenerative diseases. It has been shown that its …
[HTML][HTML] Studying the collective motions of the adenosine A2A receptor as a result of ligand binding using principal component analysis
M Martínez-Archundia, J Correa-Basurto… - Journal of …, 2019 - Taylor & Francis
Adenosine receptors (ARs) belong to family A of GPCRs that are involved in many diseases,
including cerebral and cardiac ischemic diseases, immune and inflammatory disorders, etc …
including cerebral and cardiac ischemic diseases, immune and inflammatory disorders, etc …
Destabilizing the AXH tetramer by mutations: mechanisms and potential antiaggregation strategies
The AXH domain of protein Ataxin 1 is thought to play a key role in the misfolding and
aggregation pathway responsible for Spinocerebellar ataxia 1. For this reason, a molecular …
aggregation pathway responsible for Spinocerebellar ataxia 1. For this reason, a molecular …
Aminoacid substitutions in the glycine zipper affect the conformational stability of amyloid beta fibrils
The aggregation of amyloid-beta peptides is associated with the pathogenesis of
Alzheimer's disease. The hydrophobic core of the amyloid beta sequence contains a GxxxG …
Alzheimer's disease. The hydrophobic core of the amyloid beta sequence contains a GxxxG …
Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics
Background Molecular phenomena driving pathological aggregation in neurodegenerative
diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 …
diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 …