The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical
role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor …

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in
macrophages but its role in atherosclerosis is still poorly understood. Global deletion of …

The C-type lectin receptor–Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective
antifungal immunity within the central nervous system (CNS), as human deficiency in …

Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to
different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial …

Kinase signaling in the tiered activation of inflammasomes and associated pyroptosis is a
prime therapeutic target for inflammatory diseases. While MAPKs subsume pivotal roles …

Age-related hearing loss is the most common sensory disorder worldwide that contributes to
numerous health conditions in the aging population. Despite its prevalence, current …

Pyroptosis is a host immune strategy to defend against Mycobacterium tuberculosis (Mtb)
infection. S100A4, a calcium-binding protein that plays an important role in promoting …

The adaptor protein CARD9 is in charge of mediating signals from PRRs of myeloid cells to
downstream transcription factor NF-κB. CARD9 plays an indispensable role in innate …

Sepsis is characterized by systemic inflammation, it's caused by primary infection of
pathogenic microorganisms or secondary infection of damaged tissue. In this study, we …