The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Highlights•miRNAs and RISC are located near synapses.•miRNAs regulate local protein
synthesis in dendrites and axons.•miRNAs play important roles in synapse development and …

Protein turnover, the net result of protein synthesis and degradation, enables cells to
remodel their proteomes in response to internal and external cues. Previously, we analyzed …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength
to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on …

One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD). Despite
the pervasiveness of AD being considerable, the rates of both diagnosis and therapy are …

MicroRNAs (miRNAs, miRs) are small (21–25 nucleotides) endogenous and noncoding
RNAs involved in many cellular processes such as apoptosis, development, proliferation …

Discrepancy in synaptic structural plasticity is one of the earliest manifestations of the
neurodegenerative state. In prion diseases, a reduction in synapses and dendritic spine …