Despite colorectal cancer remaining a leading worldwide cause of cancer-related death,
there remains a paucity of effective treatments for advanced disease. The molecular …

Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell
disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …

Background Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK
family of transcription factors that plays an oncogenic or tumor-suppressive role in different …

RANKL induces NFATc1, a key transcriptional factor to induce osteoclast-specific genes
such as cathepsin K, whereas transcriptional control of osteoclast survival is not fully …

Galectin-4 (Gal4) has been suggested to function as a tumor suppressor in colorectal cancer
(CRC). In order to systematically explore its function in CRC, we established a CRC cell line …

Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer.
NEPC is characterized by the loss of androgen receptor (AR) signaling and …

Hormone-dependent cancers are the most common non-cutaneous tumors experienced by
all sexes. This year, nearly 700,000 combined new cases of breast, ovarian, endometrial …

Aims The isocitrate dehydrogenase (IDH) phenotype is associated with reprogrammed
energy metabolism in glioblastoma (GBM) cells. Small nucleolar RNAs (snoRNAs) are …