Much remains to be learned about the pathogenesis of the different manifestations of
dengue virus (DENV) infections in humans. They may range from subclinical infection to …

Infection with one of the four serotypes of dengue virus (DENV) causes a wide spectrum of
clinical disease ranging from asymptomatic infection, undifferentiated fever, dengue fever …

Adiponectin is an antiatherogenic adipokine that inhibits inflammation by mechanisms that
are not completely understood. We explored the effect of adiponectin on endothelial …

Objective—In endotoxemia, lipopolysaccharide (LPS) induces a systemic inflammatory
response and intravascular coagulation. Monocytes orchestrate the innate immune …

VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate
the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and …

Emerging evidence supports a novel view of hypertension as a disease of inadequate or
aberrant responses to angiogenic growth factors (AGF). Patients with hypertension have …

Patients with acute respiratory distress syndrome are at increased risk for developing
multiorgan system dysfunction. The goal of this study was to establish an in vivo murine …

Therapeutic strategies that target and disrupt the already-formed vessel networks of growing
tumors are actively pursued. The goal of these approaches is to induce a rapid shutdown of …

The longer splice isoforms of vascular endothelial growth factor-A (VEGF-A), including
mouse VEGF164, contain a highly basic heparin-binding domain (HBD), which imparts the …

Kallistatin is a plasma protein with anti-inflammatory properties. In this study, we investigated
the role and mechanisms of kallistatin in inhibiting endothelial inflammation through its …