Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …

Cell migration is a highly integrated multistep process that orchestrates embryonic
morphogenesis; contributes to tissue repair and regeneration; and drives disease …

Biosensors based on the principle of Förster (or fluorescence) resonance energy transfer
(FRET) have shed new light on the spatiotemporal dynamics of signaling molecules. Among …

Growing evidence suggests that the physical properties of the cellular microenvironment
influence cell migration. However, it is not currently understood how active physical …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility
to inhibitors of Na+/H+ exchange. Yet, the functional relationship between Na+/H+ exchange …

Rho guanosine triphosphatases (GTPases) are master regulators of cell signaling, but how
they are regulated depending on the cellular context is unclear. We found that the …