Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Macrophages undergoing M1-versus M2-type polarization differ significantly in their cell
metabolism and cellular functions. Here, global quantitative time-course proteomics and …

Improvements in early interventions after acute myocardial infarction (AMI), notably, the
increased use of timely reperfusion therapy, have increased survival dramatically in recent …

A comprehensive understanding of the changes in gene expression in cell types involved in
idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Macrophages respond to microbial ligands and various noxious cues by initiating an
inflammatory response aimed at eliminating the original pathogenic insult. Transition of …

Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

Classically (M1) and alternatively activated (M2) macrophages exhibit distinct phenotypes
and functions. It has been difficult to dissect macrophage phenotypes in vivo, where a …

As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …