During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …

BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring
angiogenesis assays, in which developing microvessels undergo many key features of …

Cancer cells are able to proliferate at accelerated rates within the confines of a three-
dimensional (3D) extracellular matrix (ECM) that is rich in type I collagen. The mechanisms …

Over the last years, the relevance of the matrix metalloproteinase (MMP) family in cancer
research has grown considerably. These enzymes were initially associated with the invasive …