Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …

INTRODUCTION We aimed to describe baseline amyloid‐beta (Aβ) and tau‐positron
emission tomograrphy (PET) from Longitudinal Early‐onset Alzheimer's Disease Study …

BACKGROUND AND PURPOSE: With the utility of hybrid τ PET/MR imaging in the
screening, diagnosis, and follow-up of individuals with neurodegenerative diseases, we …

The accumulation of tau abnormality in sporadic Alzheimer's disease is believed typically to
follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges …

Background: Loneliness has been declared an “epidemic” associated with negative
physical, mental, and cognitive health outcomes such as increased dementia risk. Less is …

INTRODUCTION Spatial extent‐based measures of how far amyloid beta (Aβ) has spread
throughout the neocortex may be more sensitive than traditional Aβ‐positron emission …

Background Although the standardized uptake value ratio (SUVR) method is objective and
simple, cut-off optimization using global SUVR values may not reflect focal increased uptake …

Abstract Purpose The Centiloid project helps calibrate the quantitative amyloid-β (Aβ) load
into a unified Centiloid (CL) scale that allows data comparison across multi-site. How the …

Alzheimer's disease (AD) includes a long period of presymptomatic brain changes. Different
risk factors are associated with AD development, including having a family history of AD …

Background The robustness of conventional amyloid PET harmonization across tracers has
been questioned. Purpose To evaluate deep learning-based harmonization of amyloid PET …