G protein-coupled receptors (GPCRs) are involved in a vast majority of signal transduction
processes. Although they span the cell membrane, they have not been considered to be …

Abstract SEP-363856 (SEP-856) is a novel antipsychotic under clinical development. It
displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at …

Intercellular and intracellular communication processes consist of signals and
recognition/decoding apparatuses of these signals. In humans, the G protein-coupled …

G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the
body. The discovery that these receptors are voltage-sensitive has changed our …

Newer,“atypical” antipsychotics carry a lower risk of motor side-effects than older,“typical”
compounds. It has been proposed that a~ 100-fold faster dissociation from the dopamine D …

In recent years, transmembrane voltage has been found to modify agonist potencies at
several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gα i/o …

G protein-coupled receptors (GPCRs) are membrane-located proteins and, therefore, are
exposed to changes in membrane potential (VM) in excitable tissues. These changes have …

Background: The atypical antipsychotic drug aripiprazole binds with high affinity to a number
of G protein coupled receptors, including dopamine D2 receptors, where its degree of …

G protein–coupled receptors (GPCRs) are the largest class of transmembrane receptors and
serve as signal mediators to transduce information from extracellular signals such as …

The dopamine D 4 receptor (D 4 R) is expressed in the retina, prefrontal cortex, and
autonomic nervous system and has been implicated in attention deficit hyperactivity disorder …