NTRK fusion-positive cancers and TRK inhibitor therapy
N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
The cellular and molecular basis of somatosensory neuron development
Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …
The emergence of transcriptional identity in somatosensory neurons
More than twelve morphologically and physiologically distinct subtypes of primary
somatosensory neuron report salient features of our internal and external environments,,–. It …
somatosensory neuron report salient features of our internal and external environments,,–. It …
Neurotrophin-regulated signalling pathways
LF Reichardt - … Transactions of the Royal Society B …, 2006 - royalsocietypublishing.org
Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …
factors for sensory and sympathetic neurons, and have since been shown to control many …
Nociceptors—noxious stimulus detectors
CJ Woolf, Q Ma - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
Nerve growth factor signaling, neuroprotection, and neural repair
MV Sofroniew, CL Howe… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
A developmental switch in the response of DRG neurons to ETS transcription factor signaling
S Hippenmeyer, E Vrieseling, M Sigrist, T Portmann… - PLoS …, 2005 - journals.plos.org
Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal
root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their …
root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their …
Trk receptors: mediators of neurotrophin action
A Patapoutian, LF Reichardt - Current opinion in neurobiology, 2001 - Elsevier
The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
M Bibel, YA Barde - Genes & development, 2000 - genesdev.cshlp.org
Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …
of the nervous system. They are generated in remarkable numbers, particularly in higher …
Neurotrophins: mediators and modulators of pain
S Pezet, SB McMahon - Annu. Rev. Neurosci., 2006 - annualreviews.org
The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …
survival and growth. Over the past decade, considerable evidence has accumulated from …