The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be
modifiable by the management of risk factors. While several recent guidelines and …

The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Temporal organization of physiology is critical for human health. In the past, humans
experienced predictable periods of daily light and dark driven by the solar day, which …

Stress related disorders such as depression and anxiety are leading sources of disability
worldwide, and current treatment methods such as conventional antidepressant medications …

Depression is highly common throughout the life course and dementia is common in late life.
Depression has been linked with dementia, and growing evidence implies that the timing of …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …