Rare copy-number variants as modulators of common disease susceptibility
Abstract Background Copy-number variations (CNVs) have been associated with rare and
debilitating genomic disorders (GDs) but their impact on health later in life in the general …
debilitating genomic disorders (GDs) but their impact on health later in life in the general …
Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment
VR Bourque, C Poulain, C Proulx, CA Moreau… - Translational …, 2024 - nature.com
There is widespread overlap across major psychiatric disorders, and this is the case at
different levels of observations, from genetic variants to brain structures and function and to …
different levels of observations, from genetic variants to brain structures and function and to …
Genome-wide CNV analysis uncovers novel pathogenic regions in cohort of five multiplex families with neurodevelopmental disorders
BU Mudassir, MA Alotaibi, N Kizilbash, D Alruwaili… - Heliyon, 2023 - cell.com
Structural reorganization of chromosomes by genomic duplications and/or deletions are
known as copy number variations (CNVs). Pathogenic and disease susceptible CNVs alter …
known as copy number variations (CNVs). Pathogenic and disease susceptible CNVs alter …
[PDF][PDF] Endorsing complexity through diversity: computational psychiatry meets big data analytics
Brain sciences have recently been argued to be the most data-rich speciality in medicine (1).
The abundance of biomedical data is partly explained by the neurosciences' use of …
The abundance of biomedical data is partly explained by the neurosciences' use of …
Using rare genetic mutations to revisit structural brain asymmetry
Asymmetry between the left and right hemisphere is a key feature of brain organization.
Hemispheric functional specialization underlies some of the most advanced human-defining …
Hemispheric functional specialization underlies some of the most advanced human-defining …
High-effect gene-coding variants impact cognition, mental well-being, and neighborhood safety substrates in brain morphology
J Kopal, G Huguet, J Marotta, S Aggarwal, N Osayande… - medRxiv, 2024 - medrxiv.org
Our genetic makeup, together with environmental and social influences, shape our brain's
development. Yet, the imaging genetics field has struggled to integrate all these modalities …
development. Yet, the imaging genetics field has struggled to integrate all these modalities …
Copy-number variants as modulators of common disease susceptibility
ABSTRACT Background Copy-number variations (CNVs) have been associated with rare
and debilitating genomic syndromes but their impact on health later in life in the general …
and debilitating genomic syndromes but their impact on health later in life in the general …
Knowledge-Based Prioritization of Genomic Variations: A Quest for Detailed Understanding the Genetic Architecture of Diseases
IY Iourov - 2023 - preprints.org
Understanding the genetic architecture of a disease is crucial for development of valid
diagnostic and therapeutic interventions. The analysis of genomic variations associated with …
diagnostic and therapeutic interventions. The analysis of genomic variations associated with …
On the Neurobiological Basis of Chronotype: Insights from a Multimodal Population Neuroscience Study
The rapid shifts of society have brought about changes in human behavioral patterns, with
increased evening activities, increased screen time, and postponed sleep schedules. As an …
increased evening activities, increased screen time, and postponed sleep schedules. As an …