Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

Accumulating clinical evidence indicates extensive inter-individual variations in the
effectiveness and adverse effects of standard treatment protocols, which are largely …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …

Cigarette smoke is a major health risk factor which significantly increases the incidence of
diseases including lung cancer and respiratory infections. However, there is increasing …

The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and
evolving field of research. CYPs are present and active in the brain, with heterogeneous …

J. Neurochem.(2011) 118, 806–815. Abstract The cytochrome P450‐mediated synthesis of
dopamine from tyramine has been shown in vitro. The aim of the present study was to …

Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence
disorder has been well established, the influence of methadone pharmacokinetics in dose …