The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Breast cancer is the second leading cause of cancer deaths among women. The
development of breast cancer is a multi-step process involving multiple cell types, and its …

The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …

In recent years, conventional treatments including surgery, chemotherapy and radiotherapy
have been the main approaches in tumour therapy. Cancer immunotherapy is a new …

TP53 mutations are associated with poor outcomes in acute myeloid leukemia (AML). The
prognostic impact of mutant TP53 (TP53 mut) variant allelic frequency (VAF) is not well …