Liver transplantation has been identified as the most effective treatment for patients with end-
stage liver diseases. However, hepatic ischemia reperfusion injury (IRI) is associated with …

Surgery remains to be the mainstay of treatment for hepatocellular carcinoma (HCC).
Nonetheless, its therapeutic efficacy is significantly impaired by postoperative recurrence …

Hypothermic Oxygenated Perfusion (HOPE) of the liver can reduce the incidence of early
allograft dysfunction (EAD) and failure in extended criteria donors (ECD) grafts, although …

Background & Aims Liver graft utilization rates are a hot topic due to the worldwide organ
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …

Mitochondria are attractive targets for novel molecules to limit IRI-associated inflammation.
Although dynamic preservation techniques could serve as delivery tool for new therapeutic …

Although the utilization of donation after circulatory death donors (DCDs) for liver
transplantation (LT) has increased steadily, much controversy remains, and no common …

Inflammation is crucial to tumorigenesis and the development of metastasis. Hepatic
ischemia/reperfusion injury (IRI) is an unresolved problem in liver resection and …

Background Hepatic ischemia–reperfusion injury (IRI) in donation after cardiac death (DCD)
donors is a major determinant of transplantation success. Endoplasmic reticulum (ER) stress …

The risk of cancer recurrence after liver surgery mainly depends on tumor biology, but
preclinical and clinical evidence suggests that the degree of perioperative liver injury plays a …

Background: Hypothermic oxygenated machine perfusion (HOPE) is a novel organ-
preservation technology designed to optimize organ quality. However, the effects of HOPE …