The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …

Identifying molecular alterations in normal tissue adjacent to cancer is important for
understanding cancer aetiology and designing preventive measures. Here we analyse the …

Background Vitamin D has anticarcinogenic and immune-related properties and may protect
against some diseases, including breast cancer. Vitamin D affects gene transcription and …

Obesity is associated with widespread differential DNA methylation (DNAm) patterns, though
there have been limited overlap in the obesity‐associated cytosine–guanine nucleotide pair …

背景乳腺癌位居全球女性癌因死亡首位, 具有发病率高, 疾病负担重等特点. 目的评估1990—
2019 年中国女性乳腺癌发病率及死亡率的流行变化趋势. 方法提取《 2019 年全球疾病负担》 …

The biological mechanisms driving associations between alcohol consumption and chronic
diseases might include epigenetic modification of DNA methylation. We explored the …

Breast cancer develops over a timeframe of 2–3 decades prior to clinical detection. Given
this prolonged latency, it is somewhat unexpected from a biological perspective that obesity …

Using a murine model of basal-like breast cancer, we tested the hypothesis that chronic
obesity, an established breast cancer risk and progression factor in women, induces …

Domestication is one of the strongest examples of artificial selection and has produced
some of the most extreme within-species phenotypic variation known. In the case of the …