Atherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for
atherosclerosis progression that is associated with the increased incidence of ischemic …

This manuscript reviews the CYP-mediated production of oxylipins and the current known
function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families …

Abstract Objectives 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a metabolite of
arachidonic acid catalysed by cytochrome P450 enzymes and plays an important role in cell …

20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure,
cerebral blood flow and neuronal death following ischemia. Numerous human genetic …

Epidemiological studies demonstrate that there are sex differences in the incidence,
prevalence, and outcomes of cerebrovascular disease (CVD). The present study compared …

Background and Purpose The G‐protein‐coupled receptor GPR75 (Gq) and its ligand, the
cytochrome P450‐derived vasoactive eicosanoid 20‐hydroxyeicosatetraenoic acid (20 …

Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …

We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …

Ischemic cerebral stroke is a severe medical condition that affects about 15 million people
every year and is the second leading cause of death and disability globally. Ischemic stroke …

Objectives The study sought to examine the impact of longitudinal changes in depressive
symptoms in middle-aged adults before and after their first stroke, and the impact of different …