Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Enzymes play a crucial role in many biological processes which require harnessing and
converting free chemical energy into kinetic forces in order to accomplish tasks. Enzymes …

We review the effects of molecular crowding on solute diffusion in solution and in cellular
aqueous compartments and membranes. Anomalous diffusion, in which mean squared …

To begin to elucidate the principles of intermolecular dynamics in the crowded environment
of cells, employing Brownian dynamics (BD) simulations, we examined possible mechanism …

Formalized rules for protein-protein interactions have recently been introduced to represent
the binding and enzymatic activities of proteins in cellular signaling. Rules encode an …

Systems biology seeks to develop a complete understanding of cellular mechanisms by
studying the functions of intra-and inter-cellular molecular interactions that trigger and …

Abstract Systems Biology has taken advantage of computational tools and high-throughput
experimental data to model several biological processes. These include signaling, gene …

Synaptic plasticity is thought to underlie learning and memory, but the complexity of the
interactions between the ion channels, enzymes and genes that are involved in synaptic …

The effect of cellular crowding environments on protein structure and stability is a key issue
in molecular and cellular biology. The classical view of crowding emphasizes the volume …

We present a new method for the global registration of several overlapping three-
dimensional (3D) surfaces sampled on an object. The method is based on the ICP algorithm …