Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

The presence of nitrates and nitrites in food is associated with an increased risk of
gastrointestinal cancer and, in infants, methemoglobinemia. Despite the physiologic roles for …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo
generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate …

Aims Reduced bioavailability of endogenous nitric oxide (NO) is a central
pathophysiological event in hypertension and other cardiovascular diseases. Recently, it …

We tested the hypothesis that shortterm nitrite therapy reverses vascular endothelial
dysfunction and large elastic artery stiffening with aging, and reduces arterial oxidative …

Aim Despite prompt revascularization of acute myocardial infarction (AMI), substantial
myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI) …

BACKGROUND: Japanese longevity is the highest in the world. This is partly explained by
low occurrence of cardiovascular diseases, which in turn is attributed to the Japanese …

It is now accepted that the anion nitrite, once considered an inert oxidation product of nitric
oxide (NO), contributes to hypoxic vasodilation, physiological blood pressure control, and …