Get closer and make hotspots: liquid–liquid phase separation in plants

J Kim, H Lee, HG Lee, PJ Seo - EMBO reports, 2021 - embopress.org
Liquid–liquid phase separation (LLPS) facilitates the formation of membraneless
compartments in a cell and allows the spatiotemporal organization of biochemical reactions …

Emerging roles of peroxisomes in viral infections

AR Ferreira, M Marques, B Ramos, JC Kagan… - Trends in Cell …, 2022 - cell.com
Peroxisomes, essential subcellular organelles that fulfill important functions in lipid and
reactive oxygen species metabolism, have recently emerged as key players during viral …

PEX5 translocation into and out of peroxisomes drives matrix protein import

ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

Peroxisome biogenesis initiated by protein phase separation

R Ravindran, IOL Bacellar, X Castellanos-Girouard… - Nature, 2023 - nature.com
Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both
rare and prevalent diseases are caused by their dysfunction. Among disease-causing …

Comparative genomics of peroxisome biogenesis proteins: making sense of the PEX proteins

RLM Jansen, C Santana-Molina… - Frontiers in cell and …, 2021 - frontiersin.org
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a
comparative genomics approach, we clarify the evolutionary relationships between the 37 …

ATP-Dependent Steps in Peroxisomal Protein Import

HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

Liquid-liquid phase transition drives intra-chloroplast cargo sorting

M Ouyang, X Li, J Zhang, P Feng, H Pu, L Kong, Z Bai… - Cell, 2020 - cell.com
In eukaryotic cells, organelle biogenesis is pivotal for cellular function and cell survival.
Chloroplasts are unique organelles with a complex internal membrane network. The …

Systematic multi‐level analysis of an organelle proteome reveals new peroxisomal functions

E Yifrach, D Holbrook‐Smith, J Bürgi… - Molecular systems …, 2022 - embopress.org
Seventy years following the discovery of peroxisomes, their complete proteome, the peroxi‐
ome, remains undefined. Uncovering the peroxi‐ome is crucial for understanding …

Import and quality control of peroxisomal proteins

M Rudowitz, R Erdmann - Journal of Cell Science, 2023 - journals.biologists.com
Peroxisomes are involved in a multitude of metabolic and catabolic pathways, as well as the
innate immune system. Their dysfunction is linked to severe peroxisome-specific diseases …

Dynamic regulation of peroxisomes and mitochondria during fungal development

R Navarro-Espíndola, F Suaste-Olmos… - Journal of Fungi, 2020 - mdpi.com
Peroxisomes and mitochondria are organelles that perform major functions in the cell and
whose activity is very closely associated. In fungi, the function of these organelles is critical …