Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Purpose Measurement of muscle mass is paramount in the screening and diagnosis of
sarcopenia. Besides muscle quantity however, also quality assessment is important …

Loss of muscle mass and strength with aging, termed sarcopenia is accelerated in several
comorbidities including chronic heart failure (CHF) and chronic obstructive pulmonary …

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions
upstream of the disabling cascade. The lack of a unique operational definition for physical …

Aging is often accompanied by declines in physical functioning which impedes older adults'
quality of life, sense of independence, and ability to perform daily tasks. Age-related …

The role of body composition in patients with heart failure (HF) has been receiving much
attention in the last few years. Particularly, reduced lean mass (LM), the best surrogate for …

In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

Intensive care unit-acquired weakness (ICU-AW), a common neuromuscular complication
associated with patients in the ICU, is a type of skeletal muscle dysfunction that commonly …

Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary
drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of …

Background Reductions in muscle size and strength occur with aging. These changes can
be mitigated by participation in resistance training. At present, it is unknown if sex …