Marek's disease virus: from miasma to model

N Osterrieder, JP Kamil, D Schumacher… - Nature Reviews …, 2006 - nature.com
Marek's disease virus (MDV) is an oncogenic herpesvirus that causes various clinical
syndromes in its natural host, the chicken. MDV has long been of interest as a model …

Marek's disease in chickens: a review with focus on immunology

N Boodhoo, A Gurung, S Sharif, S Behboudi - Veterinary research, 2016 - Springer
Abstract Marek's disease (MD), caused by Marek's disease virus (MDV), is a commercially
important neoplastic disease of poultry which is only controlled by mass vaccination …

Virus-induced immunosuppression in chickens

IM Gimeno, KA Schat - Avian diseases, 2018 - meridian.allenpress.com
SUMMARY A healthy immune system is a cornerstone for poultry production. Any factor
diminishing the immune responses will affect production parameters and increase cost …

Marek's disease vaccines: a solution for today but a worry for tomorrow?

IM Gimeno - Vaccine, 2008 - Elsevier
Marek's disease (MD) is a lymphoproliferative disease of chickens that, in the absence of
control measures, is capable of causing devastating losses in commercial poultry flocks. MD …

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus

AC Brown, SJ Baigent, LP Smith… - Proceedings of the …, 2006 - National Acad Sciences
Marek's disease virus (MDV) is an oncogenic herpesvirus that induces fatal T cell
lymphomas in chickens. With more than 20 billion doses of vaccine used annually …

Use of Marek's disease vaccines: could they be driving the virus to increasing virulence?

F Davison, V Nair - Expert review of vaccines, 2005 - Taylor & Francis
Marek's disease (MD) is an economically important neoplastic disease of poultry. MD almost
devastated the poultry industry in the 1960s but the disease was brought under control after …

Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance

AM Conradie, LD Bertzbach, J Trimpert… - PLoS …, 2020 - journals.plos.org
Modified-live herpesvirus vaccines are widely used in humans and animals, but field strains
can emerge that have a higher virulence and break vaccinal protection. Since the …

Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin‐1

U Schwertassek, Y Balmer, M Gutscher… - The EMBO …, 2007 - embopress.org
The thiol‐disulfide oxidoreductase thioredoxin‐1 (Trx1) is known to be secreted by
leukocytes and to exhibit cytokine‐like properties. Extracellular effects of Trx1 require a …

MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs

Y Yao, Y Zhao, H Xu, LP Smith, CH Lawrie… - Journal of …, 2008 - Am Soc Microbiol
Research over the last few years has demonstrated the increasing role of microRNAs
(miRNAs) as major regulators of gene expression in diverse cellular processes and …

Marek's disease virus virulence genes encode circular RNAs

AS Chasseur, G Trozzi, C Istasse, A Petit… - Journal of …, 2022 - Am Soc Microbiol
Circular RNAs (circRNAs) are a recently rediscovered class of functional noncoding RNAs
that are involved in gene regulation and cancer development. Next-generation sequencing …