Purpose Recent years have seen a change in the way that clinical trials are being
conducted. There has been a rise of designs more flexible than traditional adaptive and …

'Multistage testing with adaptive designs' was the title of an article by Peter Bauer that
appeared 1989 in the German journal Biometrie und Informatik in Medizin und Biologie. The …

Adaptive designs can make clinical trials more flexible by utilising results accumulating in
the trial to modify the trial's course in accordance with pre-specified rules. Trials with an …

Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R
describes the common underlying theory of multiple comparison procedures through …

Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without
compromising the validity of conclusions and it is essential to distinguish pre-planned from …

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical
industry, academia, and regulatory agencies, this volume explores the rapidly growing area …

Adaptive designs allow planned modifications based on data accumulating within a study.
The promise of greater flexibility and efficiency stimulates increasing interest in adaptive …

Abstract Purpose of Review The goal of this paper is to review recent data on biomedical,
behavioral, and structural HIV prevention interventions for adolescents and young adults …

Dedifferentiated liposarcoma (DDLPS) is a rare, aggressive liposarcoma associated with
poor prognosis. First-line treatment for advanced/metastatic DDLPS is systemic …

The COVID-19 pandemic has led to an unprecedented response in terms of clinical
research activity. An important part of this research has been focused on randomized …