The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

Mitochondrial and lysosomal function are intricately related and critical for maintaining
cellular homeostasis, as highlighted by multiple diseases linked to dysfunction of both …

VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous
studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like …

Lipid transfer proteins mediate nonvesicular transport of lipids at membrane contact sites to
regulate the lipid composition of organelle membranes. Recently, a new type of bridge-like …

The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical
manifestations caused by mutations in VPS13A and XK, respectively. Key features of these …

Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …

A single particle cryo-EM reconstruction of an∼ 160-kD N-terminal fragment of the lipid
transport protein VPS13 reveals an∼ 160-Å long channel lined with hydrophobic residues …