Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

There has been an explosion in the number of papers discussing the hypothesis
of'pathogenic spread'in neurodegenerative disease—the idea that abnormal forms of …

The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the
infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

The etiologies of neurodegenerative diseases may be diverse; however, a common
pathological denominator is the formation of aberrant protein conformers and the occurrence …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Air pollution exposures have been linked to neuroinflammation and neuropathology.
Autopsy samples of the frontal cortex from control (n= 8) and pollution-exposed (n= 35) …

Neurodegenerative disorders such as Alzheimer disease, Parkinson disease,
frontotemporal dementia, Huntington disease and Creutzfeldt–Jakob disease (CJD) are …

Infectious prions containing the pathogenic conformer of the mammalian prion protein
(PrPSc) can be produced de novo from a mixture of the normal conformer (PrPC) with RNA …