Broad conformational ensembles make intrinsically disordered proteins or regions
entropically intriguing. Although methodologically challenging and understudied, emerging …

The Lipari-Szabo generalized order parameter probes the picosecond to nanosecond time
scale motions of a protein and is useful for rationalizing a multitude of biological processes …

For over half a century, it has been known that protein molecules naturally undergo
extensive structural fluctuations, and that these internal motions are intimately related to their …

Proteins unfold under different environmental insults, among which heat, cold, high pressure
and chaotropic agents. Understanding the mechanisms that determine unfolding under each …

By converting a disordered polymer into a globular structure, protein folding reduces many
conformational degrees of freedom, resulting in a significant conformational entropy penalty …

For over half a century, it has been known that protein molecules naturally undergo
extensive structural fluctuations, and that these internal motions are intimately related to their …