Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
Nanomaterials in anticancer applications and their mechanism of action-A review
The current challenges in cancer treatment using conventional therapies have made the
emergence of nanotechnology with more advancements. The exponential growth of …
emergence of nanotechnology with more advancements. The exponential growth of …
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling
Abstract Nanocrystals have contributed to exciting improvements in the delivery of poorly
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …
Recent progress of nanocarrier-based therapy for solid malignancies
QY Wei, YM Xu, ATY Lau - Cancers, 2020 - mdpi.com
Simple Summary Although conventional anti-cancer drugs have been the footstone in the
fight against cancer, yet they are far from optimal due to issues related with indiscriminate …
fight against cancer, yet they are far from optimal due to issues related with indiscriminate …
Drug nanocrystals: Fabrication methods and promising therapeutic applications
IS Mohammad, H Hu, L Yin, W He - International journal of pharmaceutics, 2019 - Elsevier
The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …
[HTML][HTML] Injected nanocrystals for targeted drug delivery
Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the
advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals …
advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals …
Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy
L Tu, G Wang, N Qi, W Wu, W Zhang, J Feng - International journal of …, 2020 - Elsevier
Chitosan is widely used as a permeation enhancer for oral drug delivery, although its
drawbacks include a limited enhancement of drug bioavailability and an inability to form …
drawbacks include a limited enhancement of drug bioavailability and an inability to form …
Nanocrystals: A perspective on translational research and clinical studies
Poorly soluble small molecules typically pose translational hurdles owing to their low
solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile …
solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile …
Paclitaxel drug delivery systems: Focus on nanocrystals' surface modifications
Paclitaxel (PTX) is a chemotherapeutic agent that belongs to the taxane family and which
was approved to treat various kinds of cancers including breast cancer, ovarian cancer …
was approved to treat various kinds of cancers including breast cancer, ovarian cancer …