Multiple system atrophy (MSA) is a rare oligodendroglial α-synucleinopathy characterized by
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …

Abstract Introduction Alpha-synuclein (αSyn) aggregates are definite pathological hallmarks
of α-synucleinopathies. Seeding amplification assays (SAAs) have been developed to detect …

Background Misfolded α‐synuclein (αSyn) aggregates (αSyn‐seeds) in cerebrospinal fluid
(CSF) are biomarkers for synucleinopathies such as Parkinson's disease (PD). αSyn‐seeds …

Background Heterozygous GAA expansions in the FGF14 gene have been related to
autosomal dominant cerebellar ataxia (SCA27B‐MIM: 620174). Whether they represent a …

Recognizing and characterizing bradykinesia is a critical issue in movement disorders.
Bradykinesia is the core symptom for the definition of parkinsonism and for the diagnosis of …

The pathophysiology of Parkinson's disease (PD) tremor remains incompletely understood
and there is a lack of clinical trials specifically addressing its pharmacological treatment …

Abstract Background The recent International Parkinson and Movement Disorder Society
diagnostic criteria for multiple system atrophy (MDS‐MSA) have been developed to improve …

The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …

Background and Objectives Orthostatic hypotension (OH) increases dementia risk in
patients with Parkinson disease (PD), although the underlying mechanisms and whether a …

Background The accumulation of α-synuclein (α-syn), an essential step in PD development
and progression, is observed not only in neurons but also in glia, including astrocytes. The …