Multiple system atrophy: at the crossroads of cellular, molecular and genetic mechanisms
N Stefanova, GK Wenning - Nature Reviews Neuroscience, 2023 - nature.com
Multiple system atrophy (MSA) is a rare oligodendroglial α-synucleinopathy characterized by
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis
D Yoo, JI Bang, C Ahn, VN Nyaga, YE Kim… - Parkinsonism & Related …, 2022 - Elsevier
Abstract Introduction Alpha-synuclein (αSyn) aggregates are definite pathological hallmarks
of α-synucleinopathies. Seeding amplification assays (SAAs) have been developed to detect …
of α-synucleinopathies. Seeding amplification assays (SAAs) have been developed to detect …
Accurate detection of α‐synuclein seeds in cerebrospinal fluid from isolated rapid eye movement sleep behavior disorder and patients with Parkinson's disease in the …
L Concha‐Marambio, S Weber, CM Farris… - movement …, 2023 - Wiley Online Library
Background Misfolded α‐synuclein (αSyn) aggregates (αSyn‐seeds) in cerebrospinal fluid
(CSF) are biomarkers for synucleinopathies such as Parkinson's disease (PD). αSyn‐seeds …
(CSF) are biomarkers for synucleinopathies such as Parkinson's disease (PD). αSyn‐seeds …
Natural History and Phenotypic Spectrum of GAA‐FGF14 Sporadic Late‐Onset Cerebellar Ataxia (SCA27B)
Background Heterozygous GAA expansions in the FGF14 gene have been related to
autosomal dominant cerebellar ataxia (SCA27B‐MIM: 620174). Whether they represent a …
autosomal dominant cerebellar ataxia (SCA27B‐MIM: 620174). Whether they represent a …
[HTML][HTML] Redefining bradykinesia
Recognizing and characterizing bradykinesia is a critical issue in movement disorders.
Bradykinesia is the core symptom for the definition of parkinsonism and for the diagnosis of …
Bradykinesia is the core symptom for the definition of parkinsonism and for the diagnosis of …
[HTML][HTML] Pharmacological treatment of tremor in Parkinson's disease revisited
W Pirker, R Katzenschlager, M Hallett… - Journal of Parkinson's …, 2023 - content.iospress.com
The pathophysiology of Parkinson's disease (PD) tremor remains incompletely understood
and there is a lack of clinical trials specifically addressing its pharmacological treatment …
and there is a lack of clinical trials specifically addressing its pharmacological treatment …
Pathological validation of the MDS criteria for the diagnosis of multiple system atrophy
S Virameteekul, T Revesz, Z Jaunmuktane… - Movement …, 2023 - Wiley Online Library
Abstract Background The recent International Parkinson and Movement Disorder Society
diagnostic criteria for multiple system atrophy (MDS‐MSA) have been developed to improve …
diagnostic criteria for multiple system atrophy (MDS‐MSA) have been developed to improve …
[HTML][HTML] Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad
K Reddy, BV Dieriks - Molecular Neurodegeneration, 2022 - Springer
The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …
Association between orthostatic hypotension and dementia in patients with Parkinson disease and multiple system atrophy
I Ruiz Barrio, Y Miki, ZT Jaunmuktane, T Warner… - Neurology, 2023 - AAN Enterprises
Background and Objectives Orthostatic hypotension (OH) increases dementia risk in
patients with Parkinson disease (PD), although the underlying mechanisms and whether a …
patients with Parkinson disease (PD), although the underlying mechanisms and whether a …
[HTML][HTML] α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
Background The accumulation of α-synuclein (α-syn), an essential step in PD development
and progression, is observed not only in neurons but also in glia, including astrocytes. The …
and progression, is observed not only in neurons but also in glia, including astrocytes. The …