Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
F Skoulidis, JV Heymach - Nature Reviews Cancer, 2019 - nature.com
The impressive clinical activity of small-molecule receptor tyrosine kinase inhibitors for
oncogene-addicted subgroups of non-small-cell lung cancer (for example, those driven by …
oncogene-addicted subgroups of non-small-cell lung cancer (for example, those driven by …
[HTML][HTML] Evolution of molecular targeted cancer therapy: mechanisms of drug resistance and novel opportunities identified by CRISPR-Cas9 screening
J Hou, Z He, T Liu, D Chen, B Wang, Q Wen… - Frontiers in …, 2022 - frontiersin.org
Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …
[HTML][HTML] Characterization with KRAS mutant is a critical determinant in immunotherapy and other multiple therapies for non-small cell lung cancer
M Shen, R Qi, J Ren, D Lv, H Yang - Frontiers in Oncology, 2022 - frontiersin.org
Non-small cell lung cancer (NSCLC) is a frequent type of cancer, which is mainly
characterized clinically by high aggressiveness and high mortality. KRAS oncoprotein is the …
characterized clinically by high aggressiveness and high mortality. KRAS oncoprotein is the …
A functional landscape of resistance to MEK1/2 and CDK4/6 inhibition in NRAS-mutant melanoma
TK Hayes, F Luo, O Cohen, AB Goodale, Y Lee… - Cancer research, 2019 - AACR
Combinatorial inhibition of MEK1/2 and CDK4/6 is currently undergoing clinical investigation
in NRAS-mutant melanoma. To prospectively map the landscape of resistance to this …
in NRAS-mutant melanoma. To prospectively map the landscape of resistance to this …
α‐Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells
L Yue, Y Ren, Q Yue, Z Ding, K Wang… - Oxidative Medicine …, 2021 - Wiley Online Library
As an antioxidant, α‐lipoic acid (LA) has attracted much attention to cancer research.
However, the exact mechanism of LA in cancer progression control and prevention remains …
However, the exact mechanism of LA in cancer progression control and prevention remains …