TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
'Warburg effect'controls tumor growth, bacterial, viral infections and immunity–Genetic deconstruction and therapeutic perspectives
The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …
[HTML][HTML] Glycogen accumulation and phase separation drives liver tumor initiation
Q Liu, J Li, W Zhang, C Xiao, S Zhang, C Nian, J Li… - Cell, 2021 - cell.com
Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation
JD Bailey, M Diotallevi, T Nicol, E McNeill, A Shaw… - Cell reports, 2019 - cell.com
Classical activation of macrophages (M (LPS+ IFNγ)) elicits the expression of inducible nitric
oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial …
oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial …
Fibroblasts mobilize tumor cell glycogen to promote proliferation and metastasis
Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable
isotope labeling of amino acids in cell culture coupled with quantitative, label-free …
isotope labeling of amino acids in cell culture coupled with quantitative, label-free …
[PDF][PDF] Glucose metabolism in cancer: The Warburg effect and beyond
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation
for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells …
for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells …
Molecular signatures of beef tenderness: Underlying mechanisms based on integromics of protein biomarkers from multi-platform proteomics studies
Over the last two decades, proteomics have been employed to decipher the underlying
factors contributing to variation in the quality of muscle foods, including beef tenderness …
factors contributing to variation in the quality of muscle foods, including beef tenderness …
Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy
CE Zois, AL Harris - Journal of molecular medicine, 2016 - Springer
Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …
within the tumour microenvironment and resistance to anticancer therapies. Recently …
Glucose metabolism in cancer
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation
for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells …
for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells …