[HTML][HTML] In vitro Models of Neurodegenerative Diseases

A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

The SH-SY5Y cell line: a valuable tool for Parkinson's disease drug discovery

M Pandey, V Karmakar, A Majie… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Owing to limited efficient treatment strategies for highly prevalent and
distressing Parkinson's disease (PD), an impending need emerged for deciphering new …

Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway

A Gugliandolo, F Pollastro, P Bramanti, E Mazzon - Fitoterapia, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of the nigrostriatal dopaminergic pathway with loss of substantia nigra pars …

Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson's Disease Patient

A Becerra-Calixto, A Mukherjee, S Ramirez… - Cells, 2023 - mdpi.com
Progressive accumulation of α-Synuclein (αSyn) in Lewy bodies (LBs) and loss of
dopaminergic (DA) neurons are the hallmark pathological features of Parkinson's disease …

Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson's disease

K Mihajlović, G Ceddia, N Malod-Dognin, G Novak… - Scientific Reports, 2024 - nature.com
Parkinson's disease (PD) is a complex neurodegenerative disorder without a cure. The
onset of PD symptoms corresponds to 50% loss of midbrain dopaminergic (mDA) neurons …

Parkinson's disease: exploring different animal model systems

E Khan, I Hasan, ME Haque - International journal of molecular sciences, 2023 - mdpi.com
Disease modeling in non-human subjects is an essential part of any clinical research. To
gain proper understanding of the etiology and pathophysiology of any disease, experimental …

Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer's and Parkinson's disease

MI Móvio, TH de Lima-Vasconcellos… - Seminars in Cell & …, 2023 - Elsevier
Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …

[HTML][HTML] An overall view of the most common experimental models for multiple sclerosis

S Dedoni, M Scherma, C Camoglio, C Siddi… - Neurobiology of …, 2023 - Elsevier
Multiple sclerosis (MS) is a complex chronic disease with an unknown etiology. It is
considered an inflammatory demyelinating and neurodegenerative disorder of the central …

Back and to the future: from neurotoxin‐induced to human Parkinson's disease models

M Airavaara, I Parkkinen, J Konovalova… - Current Protocols in …, 2020 - Wiley Online Library
Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by
motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as …

[HTML][HTML] From cell lines to pluripotent stem cells for modelling Parkinson's Disease

E Ferrari, A Cardinale, B Picconi, F Gardoni - Journal of Neuroscience …, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …